Frontoamygdalar Effective Connectivity in Youth Depression and Treatment Response

PH Kung; CG Davey; BJ Harrison; AJ Jamieson; KL Felmingham; T Steward

Journal article

Frontoamygdalar Effective Connectivity in Youth Depression and Treatment Response

PH Kung, CG Davey, BJ Harrison, AJ Jamieson, KL Felmingham, T Steward

Biological Psychiatry | Published : 2023

DOI: 10.1016/j.biopsych.2023.06.009

Abstract

Background: Emotion regulation deficits are characteristic of youth depression and are underpinned by altered frontoamygdalar function. However, the causal dynamics of frontoamygdalar pathways in depression and how these dynamics relate to treatment prognosis remain unexplored. This study aimed to assess frontoamygdalar effective connectivity during cognitive reappraisal in youths with depression and to test whether pathway dynamics are predictive of individual response to combined cognitive behavioral therapy plus treatment with fluoxetine or placebo. Methods: One hundred seven young people with moderate to severe depression and 94 healthy control participants completed a functional magneti..

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University of Melbourne Researchers

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

The trials involved in this study were funded by the Australian National Health and Medical Research Council (NHMRC) project grants (Grant No. 1024570, Youth Depression Alleviation -Combined Treatment trial [to CGD] and Grant No. APP1027315, Youth Depression Alleviation with Anti- inflammatory Agents trial [to CGD] ) and sponsored by Orygen, the National Centre of Excellence in Youth Mental Health, without limitations on publication. The study was supported by the NHMRC Career Development Fellowship (Grant Nos. 1061757 [to CGD] and 1124472 [to BJH] ) , NHMRC Project Grants (Grant Nos. 1024570 [to CGD] and 1064643 [to BJH] ) , NHMRC/Medical Research Future Fund Investigator Grant (Grant No. MRF1193736 [to TS] ) , a Brain & Behavior Research Foundation Young Investigator Grant (to TS) , and a University of Melbourne McKenzie Fellowship (to TS).